NuCell®IM feedback


Your comments, questions and reactions


Here at Nucleotide Nutrition we like to give you, our valued customers, an honest chance to have your say about our products. If you would like get in touch with any comments, questions or reactions about your experience using NuCell®IM please send us a message using the contact us on-site contact form.


Our team of experts will gladly reply to any questions or queries you may have and there’s a good chance that you will get to see your letter published on these pages in the near future if you so wish. Rest assured that Nucleotide Nutrition Limited will never post anyone’s communication or reveal their personal details on the website, without their explicit consent.


As you may be aware the law does not allow us to explain why a product or it’s ingredient may help a particular health condition as this constitutes making a medical claim.


Along with your feedback we will also be including comments and statements from recognised experts and healthcare professionals within this section.


As NuCell®IM is now available in our on-line shop on this site and in high streets up and down the country we are expecting these pages to fill up quite quickly so visit back regularly to see what everyone has been saying about “The natural approach to supporting a healthy immune system”.


Hectic lifestyle led to constant sniffles, but not anymore for this juggling working mother

 Mrs Elizabeth S from Nottingham is a sales manager and is married with two children. She told us “I began taking NuCell®IM roughly four years ago after being recommended the product by a friend. My son had begun day nursery and was subsequently picking up all sorts of colds and bugs, which he was passing on to the rest of the family. I was constantly sniffing and generally not feeling well at work.” One of her colleague suggested that she should take Nucell to boost her immune system.


“I have been both surprised and delighted by my health since I started taking NuCell®IM, I’ve only been ill twice! I have now been using NuCell®IM for around 4 years, and the daily use of 2 capsules a day has had a significant effect on my health, and general well being.”


Posted: 19 July 2012

Hair stylist and amateur athlete uses NuCell IM now not just grit!

Mr D from Cheltenham says “combining running my own salon, with four children, and trying to be an amateur athlete, entering running and swimming competitions led to chest related problems. I have always been naturally energetic, and managed to lead a very active life, getting through the periods of poor health with grit and determination. The biggest difference now, I guess, is that I am now able to enjoy all my activities, without the suffering.


Posted: 14 July 2012

International traveler no longer battles with fatigue and suppressed immunity

Mr H from Broadway, says: “I was recommended to use NuCell®IM to restore my immune system and general state of health. I was constantly fatigued from my international travel commitments for my work as an advisor on animal health. I would strongly recommend NuCell®IM. I started on 2 capsules daily, and was soon coping with my work commitments much better. I now take 1 capsule daily (as do my wife and mother-in-law), and my immunity and feelings of well-being remain well supported. I even recommend the use of nucleotides (like the ones in NuCell®IM) for animals with my animal health clients!”


Posted: 23 May 2011

Professor Lars McNaughton, reports on his experiences with NuCell®IM

Nucleotides: Strengthen the Immune System and Speed Recovery

Lars McNaughton Discusses his Research on Dietary Nucleotide Supplementation


Professor Lars McNaughton recently published a paper* in the prestigious Journal of Sports Medicine and Physical Fitness (JSMPF), where he looked at how nucleotide supplementation can mitigate stress on the body from endurance exercise. He sat down with Nucleotide Nutrition (at the time Pro Bio Healthcare), the producers of NuCell®IM, to answer questions about the implications of this study for athletes.


Lars McNaughton is Head of the Department of Sport, Health & Exercise Science at the University of Hull in England. A native of England who grew up in Australia, Professor McNaughton completed his PhD at the University of Oregon (home of coach Bill Bowerman and runners Steve Prefontaine, Alberto Salazar, etc).


He has published over 100 publications in peer reviewed journals during a 21 year career including stints in Australia, the US, the UK and Europe. He is a Fellow of the American College of Sports Medicine (ACSM), the Australian Association for Exercise and Sports Science (AESS) and the European College of Sports Science (ECSS).


*McNaughton, L., Bentley, David J., and Koeppel, P. (2006). The effects of a nucleotide supplement on salivary IgA and cortisol after moderate endurance exercise. J. Sports Medicine and Physical Fitness, 46:84-89.


Q: What was the purpose of the study you recently published in the Journal of Sports Medicine and Physical Fitness (JSMPF)?


A: The goal of this study was to determine whether the consumption of a dietary nucleotide supplement had any effect on endurance athletes.


The model we used was to look at stress, because that’s how athletic training works … it’s a stressor to the system. In training, an athlete stresses their system and then in recovery, the body adapts to that stress and increases its capacity. In this sense, stress is positive.


However, there are additional repercussions of stress which have negative effects on the body. For example, there is substantial evidence that over-training (or a large increase in training load and/or a major effort, such as racing a marathon) depresses the immune system. It is well documented that endurance athletes have a higher incidence of colds and other upper respiratory infections as a result.


Similarly, during and after exercise, the body releases the hormone cortisol into the bloodstream in response to stress. Cortisol is a catabolic hormone, which means that its effect is to degrade tissue. While the release of cortisol is part of the body’s normal response to stress, prolonged high levels of cortisol can possibly lead to muscle wastage, which is the opposite from what an athlete wants.


In our study we measured the stress imposed on the body by a prolonged exercise stress, and looked at the question of how dietary nucleotide supplementation affected the reaction to this stress.


Q: What were the results of the study?


A: After 60 days of supplementation, we found significant differences in the two markers between the control and the experimental groups. Those subjects who were taking the nucleotide supplement had significantly higher levels of salivary IgA than the control group. Analogously, cortisol levels were significantly lower in the experimental group than the control.


This work suggests that a dietary nucleotide supplement may offset the hormonal response associated with demanding endurance activity. Specifically, the body’s reaction to the stress of training may be lessened.


The implications are that nucleotide supplementation strengthens the immune system, leading to fewer colds and upper respiratory infections, and that it lowers the hormonal reaction to stress, meaning lower levels of cortisol during and after exercise, and thus to less tissue damage, which in turn permits faster recovery.


Q: Aren’t dietary nucleotides metabolized completely in the stomach? What benefit can oral supplementation provide?


A: The current study does show measurable benefits from dietary nucleotides, although it didn’t examine the mechanism of these benefits. The traditional view had been that nucleotide supplementation was not needed as the body could synthesize all the nucleotides needed on its own. Research over the past several years has shown that under conditions of stress, the body does utilize dietary nucleotides.


Research into dietary nucleotides is an area of active interest. In fact, I have another paper on this topic, currently undergoing the peer review process, which should be published in the next year.


Q: You looked at two markers (salivary IgA and cortisol). What relevance do these have to athletes?


A: These two markers are the most common indicators used to measure stress in the field of exercise physiology. They have multiple advantages, they are both easily measured via a test of the athlete’s saliva and since they are widely measured, this provides a broad basis for comparison with other studies.


Salivary immunoglobin (IgA) is the main form of immunoglobin found in saliva and the mucosal membranes, thus it plays a front line role in defending the body against colds and other respiratory infections. It is a readily measured marker for immune system function.


Cortisol is a hormone released when the body is under stress. While it is normal for an athlete to have a higher level of cortisol after exercise, elevated levels indicate higher stress. All things being equal, an athlete with a lower level of cortisol post-exercise will have a faster recovery, since there is less catabolism [tissue degradation] during exercise.


Together, these markers for immune function and hormonal change provide a good picture of how the body reacts to stress. Differential reactions to stress can be attributed to the supplementation regime we studied


Q: What was the protocol for the study?


A: We measured the two markers in all subjects at the start of the trial two times: prior to exercise and after a 90 minute endurance cycling test at approximately 60% of VO2max. The subjects were then provided the supplement or a placebo for 60 days, on a double blind basis (ie, neither the researchers nor the subjects knew who had the supplement and who had the placebo). At the end of the supplementation period the subjects again underwent testing for the two markers, prior to and following the 90 minute endurance cycling test.


Q: Are there any WADA or NCAA restrictions on oral nucleotide supplementation?


A: No, there are no restrictions. The ingredients in NuCell®IM simply provide a concentrated form of nucleotides, which are present in all food products to some degree.


Q: Would you recommend NuCell®IM to athletes?


A: Yes, I would. I take a nucleotide supplement every day, even though I consider myself to have a pretty balanced diet. Its not expensive, it certainly does no harm and based on our results there is a real benefit.


Posted: 13 March 2011